Ureidoglycolate dehydrogenase

Template:Short description Template:Infobox enzyme In enzymology, an ureidoglycolate dehydrogenase (Template:EC number) is an enzyme that catalyzes the chemical reaction

(S)-ureidoglycolate + NAD(P)⁺ $\rightleftharpoons$ oxalurate + NAD(P)H + H⁺

The 3 substrates of this enzyme are (S)-ureidoglycolate, NAD⁺, and NADP⁺, whereas its 4 products are oxalurate, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is (S)-ureidoglycolate:NAD(P)⁺ oxidoreductase. This enzyme participates in purine metabolism.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes Template:PDB link and Template:PDB link.

References

• Template:Cite journal

Template:1.1.1-enzyme-stub