UDP-N-acetylmuramate dehydrogenase

Template:Infobox enzyme In enzymology, an UDP-N-acetylmuramate dehydrogenase (Template:EC number) is an enzyme that catalyzes the chemical reaction

UDP-N-acetyl-alpha-D-muramate + NADP⁺ $\rightleftharpoons$ UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine + NADPH + H⁺

Thus, the two substrates of this enzyme are UDP-N-acetyl-alpha-D-muramate and NADP⁺, whereas its 3 products are UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is UDP-N-acetyl-alpha-D-muramate:NADP⁺ oxidoreductase. Other names in common use include MurB reductase, UDP-N-acetylenolpyruvoylglucosamine reductase, UDP-N-acetylglucosamine-enoylpyruvate reductase, UDP-GlcNAc-enoylpyruvate reductase, uridine diphosphoacetylpyruvoylglucosamine reductase, uridine diphospho-N-acetylglucosamine-enolpyruvate reductase, Template:Chem name. This enzyme participates in aminosugars metabolism. It employs one cofactor, FAD.

Structural studies

As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, and Template:PDB link.

References

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