Succinylglutamate desuccinylase

In enzymology, a succinylglutamate desuccinylase (Template:EC number) is an enzyme that catalyzes the chemical reaction

N-succinyl-L-glutamate + H₂O $\rightleftharpoons$ succinate + L-glutamate

Thus, the two substrates of this enzyme are N-succinyl-L-glutamate and H₂O, whereas its two products are succinate and L-glutamate.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is N-succinyl-L-glutamate amidohydrolase. Other names in common use include N2-succinylglutamate desuccinylase, SGDS, and AstE. This enzyme participates in arginine and proline metabolism.

References

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