Sepiapterin reductase (L-threo-7,8-dihydrobiopterin forming)

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Template:Infobox enzyme Sepiapterin reductase (L-threo-7,8-dihydrobiopterin forming) (Template:EC number) is an enzyme with systematic name L-threo-7,8-dihydrobiopterin:NADP+ oxidoreductase.[1][2] This enzyme catalyses the following chemical reaction

(1) L-threo-7,8-dihydrobiopterin + NADP+ sepiapterin + NADPH + H+
(2) L-threo-tetrahydrobiopterin + 2 NADP+ 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 NADPH + 2 H+

This bacterial (Chlorobium tepidum) enzyme catalyses the final step in the de novo synthesis of tetrahydrobiopterin from GTP.

References

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