Sarcosine/dimethylglycine N-methyltransferase

Template:Infobox enzyme Sarcosine/dimethylglycine N-methyltransferase (Template:EC number, ApDMT, sarcosine-dimethylglycine methyltransferase, SDMT, sarcosine dimethylglycine N-methyltransferase, S-adenosyl-L-methionine:N,N-dimethylglycine N-methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:sarcosine(or N,N-dimethylglycine) N-methyltransferase (N,N-dimethylglycine(or betaine)-forming). This enzyme catalyses the following chemical reaction

2 S-adenosyl-L-methionine + sarcosine $\rightleftharpoons$ 2 S-adenosyl-L-homocysteine + betaine (overall reaction)

(1a) S-adenosyl-L-methionine + sarcosine $\rightleftharpoons$ S-adenosyl-L-homocysteine + N,N-dimethylglycine

(1b) S-adenosyl-L-methionine + N,N-dimethylglycine $\rightleftharpoons$ S-adenosyl-L-homocysteine + betaine

This enzyme participates in biosynthesis of betaine from glycine in cyanobacterium Aphanocthece halophytica.

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