Rhamnulokinase
Template:Infobox enzyme In enzymology, a rhamnulokinase (Template:EC number) is an enzyme that catalyzes the chemical reaction
- ATP + L-rhamnulose ADP + L-rhamnulose 1-phosphate
Thus, the two substrates of this enzyme are ATP and L-rhamnulose, whereas its two products are ADP and L-rhamnulose 1-phosphate.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:L-rhamnulose 1-phosphotransferase. Other names in common use include RhuK, rhamnulokinase (phosphorylating), L-rhamnulokinase, L-rhamnulose kinase, and rhamnulose kinase. This enzyme participates in pentose and glucuronate interconversions and fructose and mannose metabolism. This enzyme can catalyze the xylulose phosphorilation:[1]
ATP + L-Xylulose ADP + L-Xylulose 1-phosphate
Structural studies
As of late 2007, 4 structures have been solved for this class of enzymes by Grueninger and Schulz with PDB accession codes Template:PDB link, Template:PDB link, Template:PDB link, and Template:PDB link.
References
- Template:Cite journal
- D.Grueninger and G.E.Schulz (2006). Structure and reaction mechanism of L-rhamnulose kinase from Escherichia coli.. J. Mol. Biol., 359, 787-797.
- D.Grueninger and G.E.Schulz (2007). Substrate spectrum of L-rhamnulose kinase related to models derived from two ternary complex structures.. FEBS Lett, 581, 3127-3130.