Protein-disulfide reductase

Template:Infobox enzyme In enzymology, a protein-disulfide reductase (Template:EC number) is an enzyme that catalyzes the chemical reaction

protein dithiol + NAD(P)+ $\rightleftharpoons$ protein disulfide + NAD(P)H + H⁺

The 3 substrates of this enzyme are protein dithiol, NAD⁺, and NADP⁺, whereas its 4 products are protein disulfide, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on a sulfur group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is protein-dithiol:NAD(P)+ oxidoreductase. Other names in common use include protein disulphide reductase, insulin-glutathione transhydrogenase, disulfide reductase, and NAD(P)H2:protein-disulfide oxidoreductase.

Structural studies

As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, and Template:PDB link.

References

• Template:Cite journal

Template:1.8-enzyme-stub