Protein-arginine deiminase
Template:Infobox enzyme In enzymology, a protein-arginine deiminase (Template:EC number) is an enzyme that catalyzes a form of post translational modification called arginine de-imination or citrullination:
- protein L-arginine + H2O protein L-citrulline + NH3
Thus, the two substrates of this enzyme are protein L-arginine (arginine residue inside a protein) and H2O, whereas its two products are protein L-citrulline and NH3:
This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amidines. The systematic name of this enzyme class is protein-L-arginine iminohydrolase. This enzyme is also called peptidylarginine deiminase.
Structural studies
As of late 2007, seven structures have been solved for this class of enzymes, with PDB accession codes Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, and Template:PDB link.
Mammalian proteins
Mammals have 5 protein-arginine deiminases, with symbols
except for rodents, there the letter case is different:
- Padi1, Padi2, Padi3, Padi4, Padi6[3]
The different case is just a historical artifact. It doesn't indicate that the rodent proteins are special.
References
Template:Carbon-nitrogen non-peptide hydrolases Template:Enzymes Template:Portal bar