Precorrin-6A reductase

Template:Short description Template:Infobox enzyme In enzymology, a precorrin-6A reductase (Template:EC number) is an enzyme that catalyzes the chemical reaction

precorrin-6A + NADPH + H⁺ $\rightleftharpoons$ precorrin-6B + NADP⁺

The three substrates of this enzyme are precorrin 6A, NADPH and a proton; its two products are precorrin 6B and NADP⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH=CH group of an acceptor with NAD or NADPH as donor. The systematic name of this enzyme class is precorrin-6B:NADP+ oxidoreductase. Other names in common use include precorrin-6X reductase, precorrin-6Y:NADP+ oxidoreductase and CobK. This enzyme is part of the biosynthetic pathway to cobalamin (vitamin B₁₂) in aerobic bacteria.

See also

• Cobalamin biosynthesis

References

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