Phosphoserine phosphatase
Template:Short description Template:Infobox enzyme
The enzyme phosphoserine phosphatase (EC 3.1.3.3) catalyzes the reversible reaction
- O-phospho-L(or D)-serine + H2O L(or D)-serine + phosphate
For example, with L-phosphoserine as substrate the hydrolysis reaction gives L-serine, with orthophosphate as byproduct:[1]
The enzyme was characterised from chicken and rat liver.[1][2] It is also present in humans, where it regulates glycine and D-serine levels.[3] The reaction is the final, irreversible, step in L-serine biosynthesis.[4][5]
The enzyme is classified as a hydrolase, specifically one acting on phosphoric monoester bonds. The systematic name is O-phosphoserine phosphohydrolase.[6]
Structural studies
As of late 2007, 12 structures have been solved for this class of enzymes, with PDB accession codes Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, and Template:PDB link.