Phosphoribosyl-ATP diphosphatase

Template:Short description Template:Infobox enzyme In enzymology, a phosphoribosyl-ATP diphosphatase (Template:EC number) is an enzyme that catalyzes the chemical reaction

1-(5-phosphoribosyl)-ATP + H₂O $\rightleftharpoons$ 1-(5-phosphoribosyl)-AMP + diphosphate

Thus, the two substrates of this enzyme are 1-(5-phosphoribosyl)-ATP and H₂O, whereas its two products are 1-(5-phosphoribosyl)-AMP and diphosphate.

This enzyme participates in histidine metabolism. It employs one cofactor, H+.

Nomenclature

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is 1-(5-phosphoribosyl)-ATP diphosphohydrolase. Other names in common use include phosphoribosyl-ATP pyrophosphatase, and phosphoribosyladenosine triphosphate pyrophosphatase.

References

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