Phosphoethanolamine/phosphocholine phosphatase
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Template:Infobox enzyme Phosphoethanolamine/phosphocholine phosphatase (EC 3.1.3.75, PHOSPHO1, 3X11A; systematic name phosphoethanolamine phosphohydrolase) is an enzyme highly expressed in mineralizing cells .[1][2][3] This enzyme is implicated in bone and cartilage formation and catalyses the following chemical reactions:
- (1) O-phosphoethanolamine + H2O ethanolamine + phosphate
- (2) phosphocholine + H2O choline + phosphate
The enzyme is a member of the haloacid dehalogenase superfamily. Like other members of this superfamily it requires a metal ion for catalysis, which is usually Mg2+, it is also active in the presence of Co2+ or Mn2+ but exhibits a lower specific activity with these metal ions.