Phosphatidylinositol N-acetylglucosaminyltransferase
Template:Short description Template:Infobox enzyme In enzymology, a phosphatidylinositol N-acetylglucosaminyltransferase (Template:EC number) is an enzyme that catalyzes the chemical reaction
- UDP-N-acetylglucosamine + phosphatidylinositol UDP + N-acetyl-D-glucosaminylphosphatidylinositol
Thus, the two substrates of this enzyme are UDP-N-acetylglucosamine and phosphatidylinositol, whereas its two products are UDP and N-acetyl-D-glucosaminylphosphatidylinositol.
The mammalian enzyme is composed of at least six subunits (PIG-A, PIG-H, PIG-C, PIG-P, PIG-Y, and GPI1). PIG-A is the catalytic subunit.
This enzyme belongs to the family of glycosyltransferases, to be specific the hexosyltransferases. The systematic name of this enzyme class is UDP-N-acetyl-D-glucosamine:1-phosphatidyl-1D-myo-inositol 6-(N-acetyl-alpha-D-glucosaminyl)transferase. Other names in common use include UDP-N-acetyl-D-glucosamine:phosphatidylinositol, N-acetyl-D-glucosaminyltransferase, uridine diphosphoacetylglucosamine, and alpha1,6-acetyl-D-glucosaminyltransferase. This enzyme participates in 3 metabolic pathways: glycosylphosphatidylinositol(gpi)-anchor, ???, and glycan structures - biosynthesis 2.
References
Template:Glycosyltransferases Template:Enzymes Template:Portal bar