Ornithine cyclodeaminase

Template:Infobox enzyme The enzyme ornithine cyclodeaminase (EC 4.3.1.12) catalyzes the chemical reaction

L-ornithine $\rightleftharpoons$ L-proline + NH₄⁺

This enzyme belongs to the family of lyases, specifically ammonia lyases, which cleave carbon-nitrogen bonds. The systematic name of this enzyme class is Lornithine ammonia-lyase (cyclizing; L-proline-forming). Other names in common use include ornithine cyclase, ornithine cyclase (deaminating), and L-ornithine ammonia-lyase (cyclizing). This enzyme participates in arginine and proline biosynthesis. It employs one cofactor, NAD⁺.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes Template:PDB link and Template:PDB link.

References

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