Nitric-oxide synthase (NAD(P)H-dependent)

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Template:Short description Template:Infobox enzyme Nitric-oxide synthase (NAD(P)H-dependent) (Template:EC number, nitric oxide synthetase, NO synthase) is an enzyme with systematic name L-arginine,NAD(P)H:oxygen oxidoreductase (nitric-oxide-forming).[1][2][3] This enzyme catalyses the following chemical reaction

2 L-arginine + 3 NAD(P)H + 3 H+ + 4 O2 ⇌ 2 L-citrulline + 2 nitric oxide + 3 NAD(P)+ + 4 H2O (overall reaction)
(1a) 2 L-arginine + 2 NAD(P)H + 2 H+ + 2 O2 ⇌ 2 N-omega-hydroxy-L-arginine + 2 NAD(P)+ + 2 H2O
(1b) 2 N-omega-hydroxy-L-arginine + NAD(P)H + H+ + 2 O2 ⇌ 2 L-citrulline + 2 nitric oxide + NAD(P)+ + 2 H2O

Nitric-oxide synthase (NAD(P)H-dependent) binds heme (iron protoporphyrin IX) and tetrahydrobiopterin.

See also

References

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Template:Dioxygenases Template:Enzymes Template:Portal bar

  1. ↑ Template:Cite journal
  2. ↑ Template:Cite journal
  3. ↑ Template:Cite journal
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