Nicotinate N-methyltransferase

Template:Short description Template:Infobox enzyme In enzymology, a nicotinate N-methyltransferase (Template:EC number) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + nicotinate $\rightleftharpoons$ S-adenosyl-L-homocysteine + N-methylnicotinate

Thus, the two substrates of this enzyme are S-adenosyl methionine and nicotinate, whereas its two products are S-adenosylhomocysteine and N-methylnicotinate.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:nicotinate N-methyltransferase. Other names in common use include furanocoumarin 8-methyltransferase, and furanocoumarin 8-O-methyltransferase. This enzyme participates in nicotinate and nicotinamide metabolism.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code Template:PDB link.

References

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