Nicotinamide-nucleotide amidase

Template:Infobox enzyme In enzymology, a nicotinamide-nucleotide amidase (Template:EC number) is an enzyme that catalyzes the chemical reaction

beta-nicotinamide D-ribonucleotide + H₂O $\rightleftharpoons$ beta-nicotinate D-ribonucleotide + NH₃

Thus, the two substrates of this enzyme are beta-nicotinamide D-ribonucleotide and H₂O, whereas its two products are beta-nicotinate D-ribonucleotide and NH₃.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is nicotinamide-D-ribonucleotide amidohydrolase. Other names in common use include NMN deamidase, nicotinamide mononucleotide deamidase, and nicotinamide mononucleotide amidohydrolase. This enzyme participates in nicotinate and nicotinamide metabolism.

References

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