Methylthioadenosine nucleosidase

Template:Infobox enzyme In enzymology, a methylthioadenosine nucleosidase (Template:EC number) is an enzyme that catalyzes the chemical reaction

S-methyl-5'-thioadenosine + H₂O $\rightleftharpoons$ S-methyl-5-thio-D-ribose + adenine

Thus, the two substrates of this enzyme are S-methyl-5'-thioadenosine and H₂O, whereas its two products are S-methyl-5-thio-D-ribose and adenine.

This enzyme belongs to the family of hydrolases, specifically those glycosylases that hydrolyse N-glycosyl compounds. The systematic name of this enzyme class is S-methyl-5'-thioadenosine adeninehyrolase. Other names in common use include 5'-methylthioadenosine nucleosidase, MTA nucleosidase, MeSAdo nucleosidase, and methylthioadenosine methylthioribohydrolase. This enzyme participates in urea cycle and metabolism of amino groups and methionine metabolism.

Structural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, and Template:PDB link.

References

• Template:Cite journal

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