Malonate-semialdehyde dehydrogenase (acetylating)

In enzymology, a malonate-semialdehyde dehydrogenase (acetylating) (Template:EC number) is an enzyme that catalyzes the chemical reaction

3-oxopropanoate + CoA + NAD(P)+ $\rightleftharpoons$ acetyl-CoA + CO₂ + NAD(P)H

The 4 substrates of this enzyme are 3-oxopropanoate, CoA, NAD⁺, and NADP⁺, whereas its 4 products are acetyl-CoA, CO₂, NADH, and NADPH.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3-oxopropanoate:NAD(P)+ oxidoreductase (decarboxylating, CoA-acetylating). This enzyme is also called malonic semialdehyde oxidative decarboxylase. This enzyme participates in 4 metabolic pathways: inositol metabolism, alanine and aspartate metabolism, beta-alanine metabolism, and propanoate metabolism.

Further reading

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