Icosanoyl-CoA synthase

Template:Infobox enzyme In enzymology, an icosanoyl-CoA synthase (Template:EC number) is an enzyme that catalyzes the chemical reaction

stearoyl-CoA + malonyl-CoA + 2 NAD(P)H + 2 H⁺ $\rightleftharpoons$ icosanoyl-CoA + CO₂ + CoA + 2 NAD(P)+ + H₂O

The 5 substrates of this enzyme are stearoyl-CoA, malonyl-CoA, NADH, NADPH, and H⁺, whereas its 6 products are icosanoyl-CoA, CO₂, CoA, NAD⁺, NADP⁺, and H₂O.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is stearoyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing). Other names in common use include acyl-CoA elongase, C18-CoA elongase, and stearoyl-CoA elongase.

References

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