Hydroxymethylglutaryl-CoA reductase

Template:Infobox enzyme In enzymology, a Hydroxymethylglutaryl-CoA reductase (Template:EC number) is an enzyme that catalyzes the chemical reaction

(R)-mevalonate + CoA + 2 NAD⁺ $\rightleftharpoons$ 3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H⁺

The 3 substrates of this enzyme are (R)-mevalonate, CoA, and NAD⁺, whereas its 3 products are 3-hydroxy-3-methylglutaryl-CoA, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is (R)-mevalonate:NAD⁺ oxidoreductase (CoA-acylating). Other names in common use include beta-hydroxy-beta-methylglutaryl coenzyme A reductase, beta-hydroxy-beta-methylglutaryl CoA-reductase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and hydroxymethylglutaryl coenzyme A reductase.

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