Holo-ACP synthase

Template:Infobox enzyme In enzymology, a holo-ACP synthase (Template:EC number) is an enzyme that catalyzes the chemical reaction

2'-(5"-triphosphoribosyl)-3'-dephospho-CoA + apo-citrate lyase $\rightleftharpoons$ holo-citrate lyase + diphosphate

Thus, the two substrates of this enzyme are 2'-(5"-triphosphoribosyl)-3'-dephospho-CoA and apo-citrate lyase, whereas its two products are holo-citrate lyase and diphosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is 2'-(5"-triphosphoribosyl)-3'-dephospho-CoA:apo-citrate lyase adenylyltransferase. Other names in common use include 2'-(5"-phosphoribosyl)-3'-dephospho-CoA transferase, 2'-(5"-triphosphoribosyl)-3'-dephospho-CoA:apo-citrate lyase, and CitX. This enzyme participates in two-component system - general.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code Template:PDB link.

References

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