Guanylate kinase
Template:Short description Template:Infobox enzyme Template:Infobox protein family
In enzymology, a guanylate kinase (Template:EC number) is an enzyme that catalyzes the chemical reaction
Thus, the two substrates of this enzyme are ATP and GMP, whereas its two products are ADP and GDP.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with a phosphate group as acceptor. This enzyme participates in purine metabolism.
Guanylate kinase catalyzes the ATP-dependent phosphorylation of GMP into GDP.[1] It is essential for recycling GMP and indirectly, cGMP. In prokaryotes (such as Escherichia coli), lower eukaryotes (such as yeast) and in vertebrates, GK is a highly conserved monomeric protein of about 200 amino acids. GK has been shown to be structurally similar to protein A57R (or SalG2R) from various strains of Vaccinia virus.[2][3][4] Systems biology analyses carried out by the team of Andreas Dräger also identified a pivotal role of this enzyme in the replication of SARS-CoV-2 within the human airways.[5][6][7]
Nomenclature
The systematic name of this enzyme class is ATP:(d)GMP phosphotransferase. Other names in common use include"
- deoxyguanylate kinase,
- 5'-GMP kinase,
- GMP kinase,
- guanosine monophosphate kinase, and
- ATP:GMP phosphotransferase.
References
Further reading
- Template:Cite journal
- Template:Cite journal
- Template:Cite journal
- Template:Cite journal
- Template:Cite journal
Template:InterPro content Template:Kinases Template:Enzymes Template:Portal bar
- ↑ Cite error: Invalid
<ref>tag; no text was provided for refs namedpmid1314905 - ↑ Template:Cite journal
- ↑ Template:Cite journal
- ↑ Template:Cite journal
- ↑ Template:Cite journal
- ↑ Template:Cite journal
- ↑ Template:Cite journal