Glyoxylate reductase (NADP+)

Template:Infobox enzyme In enzymology, a glyoxylate reductase (NADP⁺) (Template:EC number) is an enzyme that catalyzes the chemical reaction

glycolate + NADP⁺ $\rightleftharpoons$ glyoxylate + NADPH + H⁺

Thus, the two substrates of this enzyme are glycolate and NADP⁺, whereas its 3 products are glyoxylate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is glycolate:NADP⁺ oxidoreductase. Other names in common use include NADPH-glyoxylate reductase, and glyoxylate reductase (NADP⁺). This enzyme participates in pyruvate metabolism and glyoxylate and dicarboxylate metabolism.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes Template:PDB link, Template:PDB link, and Template:PDB link.

References

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