Glycolaldehyde dehydrogenase

Template:Infobox enzyme In enzymology, a glycolaldehyde dehydrogenase (Template:EC number) is an enzyme that catalyzes the chemical reaction

glycolaldehyde + NAD⁺ + H₂O $\rightleftharpoons$ glycolate + NADH + H⁺

The 3 substrates of this enzyme are glycolaldehyde, NAD⁺, and H₂O, whereas its 3 products are glycolate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is glycolaldehyde:NAD+ oxidoreductase. This enzyme is also called glycol aldehyde dehydrogenase. This enzyme participates in glyoxylate and dicarboxylate metabolism.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes Template:PDB link, Template:PDB link, and Template:PDB link.

References

• Template:Cite journal

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