Glucuronyl-galactosyl-proteoglycan 4-a-N-acetylglucosaminyltransferase

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Template:Short description Template:Infobox enzyme Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase (Template:EC number, alpha-N-acetylglucosaminyltransferase I, alpha1,4-N-acetylglucosaminyltransferase, glucuronosylgalactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase) is an enzyme with systematic name UDP-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan 4IV-alpha-N-acetyl-D-glucosaminyltransferase.[1][2] This enzyme catalyses the following chemical reaction

UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan ⇌ UDP + alpha-N-acetyl-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan

This enzyme is involved in the initiation of heparin and heparan sulfate synthesis.

References

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Template:Glycosyltransferases Template:Enzymes Template:Portal bar

  1. ↑ Template:Cite journal
  2. ↑ Template:Cite journal
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