Glucose-1-phosphate thymidylyltransferase
Template:Infobox enzyme In enzymology, a glucose-1-phosphate thymidylyltransferase (Template:EC number) is an enzyme that catalyzes the chemical reaction
- dTTP + alpha-D-glucose 1-phosphate diphosphate + dTDP-glucose
Thus, the two substrates of this enzyme are dTTP and alpha-D-glucose 1-phosphate, whereas its two products are pyrophosphate and dTDP-glucose.[1]
This enzyme belongs to the family of transferases, to be specific, those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). This enzyme participates in 3 metabolic pathways: nucleotide sugars metabolism, streptomycin biosynthesis, and polyketide sugar unit biosynthesis.[2][3]
Nomenclature
The systematic name of this enzyme class is dTTP:alpha-D-glucose-1-phosphate thymidylyltransferase. Other names in common use include:
- glucose 1-phosphate thymidylyltransferase,
- dTDP-glucose synthase, dTDP-glucose pyrophosphorylase,
- thymidine diphosphoglucose pyrophosphorylase,
- thymidine diphosphate glucose pyrophosphorylase, and
- TDP-glucose pyrophosphorylase.
Structural studies
As of late 2007, 19 structures have been solved for this class of enzymes, with PDB accession codes Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, and Template:PDB link.