GTP cyclohydrolase IIa

Template:Infobox enzyme In enzymology, a GTP cyclohydrolase IIa (Template:EC number) is an enzyme that catalyzes the chemical reaction

GTP + 3 H₂O $\rightleftharpoons$ 2-amino-5-formylamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one + 2 phosphate

Thus, the two substrates of this enzyme are GTP and H₂O, whereas its two products are 2-amino-5-formylamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one and phosphate.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is GTP 8,9-hydrolase (phosphate-forming).

References

• Template:Cite journal

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