GTP cyclohydrolase II
Template:Infobox enzyme In enzymology, a GTP cyclohydrolase II (Template:EC number) is an enzyme that catalyzes the chemical reaction
- GTP + 3 H2O formate + 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine + diphosphate
Thus, the two substrates of this enzyme are GTP and H2O, whereas its 3 products are formate, 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine, and diphosphate.
This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is GTP 7,8-8,9-dihydrolase (diphosphate-forming). Other names in common use include guanosine triphosphate cyclohydrolase II, and GTP-8-formylhydrolase. This enzyme participates in riboflavin metabolism.
Structural studies
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes Template:PDB link and Template:PDB link.
References
Template:Carbon-nitrogen non-peptide hydrolases Template:Enzymes Template:Portal bar