Erythromycin 12 hydroxylase

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Erythromycin 12 hydroxylase (Template:EC number, EryK) is an enzyme with systematic name erythromycin-D,NADPH:oxygen oxidoreductase (12-hydroxylating) .[1][2][3] This enzyme catalyses the following chemical reaction

erythromycin D + NADPH + H+ + O2 erythromycin C + NADP+ + H2O

Erythromycin 12 hydroxylase is responsible for the C-12 hydroxylation of the macrolactone ring.

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