Diaminohydroxyphosphoribosylaminopyrimidine deaminase

Template:Infobox enzyme In enzymology, a diaminohydroxyphosphoribosylaminopyrimidine deaminase (Template:EC number) is an enzyme that catalyzes the chemical reaction

2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine + H₂O $\rightleftharpoons$ 5-amino-6-(5-phosphoribosylamino)uracil + NH₃

Thus, the two substrates of this enzyme are 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and H₂O, whereas its two products are 5-amino-6-(5-phosphoribosylamino)uracil and NH₃.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds (specifically in cyclic amidines). The systematic name of this enzyme class is 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine 2-aminohydrolase. This enzyme participates in riboflavin metabolism.

Structural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, and Template:PDB link.

References

• Template:Cite journal

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