Deacetoxycephalosporin-C synthase

Template:Short description Template:Infobox enzyme In enzymology, a deacetoxycephalosporin-C synthase (Template:EC number) is an enzyme that catalyzes the chemical reaction

penicillin N + 2-oxoglutarate + O₂ $\rightleftharpoons$ deacetoxycephalosporin C + succinate + CO₂ + H₂O

The 3 substrates of this enzyme are penicillin N, 2-oxoglutarate, and O₂, whereas its 4 products are deacetoxycephalosporin C, succinate, CO₂, and H₂O.

Classification

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with 2-oxoglutarate as one donor, and the other dehydrogenated.

Nomenclature

The systematic name of this enzyme class is penicillin-N,2-oxoglutarate:oxygen oxidoreductase (ring-expanding). Other names in common use include DAOCS, penicillin N expandase, and DAOC synthase.

Biological role

This enzyme participates in penicillin and cephalosporin biosynthesis.

Structural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, and Template:PDB link.

References

• Template:Cite journal
• Template:Cite journal
• Template:Cite journal
• Template:Cite journal
• Template:Cite journal

Template:1.14-enzyme-stub