DCTP deaminase

Template:Infobox enzyme Template:Lowercase title In enzymology, a dCTP deaminase (Template:EC number) is an enzyme that catalyzes the chemical reaction

dCTP + H₂O $\rightleftharpoons$ dUTP + NH₃

Thus, the two substrates of this enzyme are dCTP and H₂O, whereas its two products are dUTP and NH₃.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is dCTP aminohydrolase. Other names in common use include deoxycytidine triphosphate deaminase, and 5-methyl-dCTP deaminase. This enzyme participates in pyrimidine metabolism.

Structural studies

As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, and Template:PDB link.

References

• Template:Cite journal

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