Cytosine deaminase

Template:Infobox enzyme In enzymology, a cytosine deaminase (Template:EC number) is an enzyme that catalyzes the chemical reaction

cytosine + H₂O $\rightleftharpoons$ uracil + NH₃

Thus, the two substrates of this enzyme are cytosine and H₂O, whereas its two products are uracil and NH₃.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is cytosine aminohydrolase. This enzyme is also called isocytosine deaminase. This enzyme participates in pyrimidine metabolism.

Structural studies

As of late 2007, 13 structures have been solved for this class of enzymes, with PDB accession codes Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, and Template:PDB link.

References

• Template:Cite journal
• Template:Cite journal

Template:3.5-enzyme-stub