Cmin

Template:Math is a term used in pharmacokinetics for the minimum blood plasma concentration reached by a drug during a dosing interval, which is the time interval between administration of two doses. This definition is slightly different from Template:Math, the concentration immediately prior to administration of the next dose. Template:Math is the opposite of Template:Math, the maximum concentration that the drug reaches. Template:Math must be above certain thresholds, such as the minimum inhibitory concentration (MIC), to achieve a therapeutic effect.

In most cases Template:Math is directly measurable. At steady state the minimum plasma concentration can also be calculated using the following equation: $$C_{min}=\frac{SFD{k}_a}{V_d(k_a-k_e)}\times (\frac{e^{-k_e\tau }}{1-e^{-k_e\tau }}-\frac{e^{-k_a\tau }}{1-e^{-k_a\tau }})$$

Template:Mvar = Salt factor

Template:Mvar = Bioavailability

Template:Mvar = Dose

Template:Math = Elimination rate constant

Template:Math = Absorption rate constant

Template:Math = Volume of distribution

Template:Mvar = Dosing interval

Template:Math is also an important parameter in bioavailability and bioequivalence studies, it is part of the pharmacokinetic information recommended for submission of investigational new drug applications.

References

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