Cholestanetetraol 26-dehydrogenase

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Template:Infobox enzyme In enzymology, a cholestanetetraol 26-dehydrogenase (Template:EC number) is an enzyme that catalyzes the chemical reaction

(25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol + NAD⁺

⇌

(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + NADH + H⁺

Thus, the two substrates of this enzyme are (25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol and NAD⁺, whereas its 3 products are (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is (25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol:NAD⁺ 26-oxidoreductase. Other names in common use include cholestanetetraol 26-dehydrogenase, 5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol dehydrogenase, TEHC-NAD oxidoreductase, 5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol:NAD⁺, and 26-oxidoreductase. This enzyme participates in bile acid biosynthesis.