Butyrate—CoA ligase
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Template:Infobox enzyme Butyrate—CoA ligase, also known as xenobiotic/medium-chain fatty acid-ligase (XM-ligase), is an enzyme (Template:EnzExplorer) that catalyzes the chemical reaction:
- ATP + a carboxylic acid + CoA AMP + diphosphate + an acyl-CoA
The 3 substrates of this enzyme are ATP, carboxylic acid, and CoA, whereas its 3 products are AMP, diphosphate, and acyl-CoA.
This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. This enzyme participates in the glycine conjugation of xenobiotics[1] and butanoate metabolism.
Nomenclature
The systematic name of this enzyme class is butanoate:CoA ligase (AMP-forming). Other names in common use include:
- butyryl-CoA synthetase, fatty acid thiokinase (medium chain),
- acyl-activating enzyme, fatty acid elongate,
- fatty acid activating enzyme,
- fatty acyl coenzyme A synthetase,
- medium chain acyl-CoA synthetase,
- butyryl-coenzyme A synthetase,
- L-(+)-3-hydroxybutyryl CoA ligase,
- xenobiotic/medium-chain fatty acid ligase, and
- short-chain acyl-CoA synthetase.
Human proteins containing this domain
References
Template:Ligases CO CS and CN Template:Enzymes Template:Portal bar