Beta-amyrin 11-oxidase

Template:Short description Template:Infobox enzyme Beta-amyrin 11-oxidase (Template:EC number, CYP88D6) is an enzyme with systematic name beta-amyrin,NADPH:oxygen oxidoreductase (hydroxylating).^[1] This enzyme catalyses the following chemical reaction

beta-amyrin + 2 O₂ + 2 NADPH + 2 H⁺

⇌

11-oxo-beta-amyrin + 3 H₂O + 2 NADP⁺ (overall reaction)

(1a) beta-amyrin + O₂ + NADPH + H⁺

⇌

11alpha-hydroxy-beta-amyrin + H₂O + NADP⁺

(1b) 11alpha-hydroxy-beta-amyrin + O₂ + NADPH + H⁺

⇌

11-oxo-beta-amyrin + 2 H₂O + NADP⁺

Beta-amyrin 11-oxidase requires cytochrome P450.

References