Benzoylformate decarboxylase

Template:Infobox enzyme The enzyme benzoylformate decarboxylase (Template:EnzExplorer) catalyzes the following chemical reaction:

benzoylformate + H⁺ $\rightleftharpoons$ benzaldehyde + CO₂

Hence, this enzyme has one substrate, benzoylformate, and two products, benzaldehyde and CO₂.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is benzoylformate carboxy-lyase (benzaldehyde-forming). Other names in common use include phenylglyoxylate decarboxylase, and benzoylformate carboxy-lyase. This enzyme participates in benzoate degradation via hydroxylation and toluene and xylene degradation. It employs one cofactor, thiamin diphosphate.

Structural studies

As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, and Template:PDB link.

References

• Template:Cite journal

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