Aromatic-amino-acid transaminase
Template:Infobox enzyme An Aromatic-amino-acid transaminase (Template:EC number) is a pyridoxal phosphate-dependent enzyme that catalyzes the general chemical reaction
- an aromatic amino acid + α-ketoglutaric acid an aromatic oxo acid + L-glutamate
The two substrates of this enzyme are an aromatic amino acid and α-ketoglutaric acid. Its products are the corresponding α-keto acid and L-glutamic acid.
For example, the enzyme characterised from Escherichia coli interconverts phenylalanine and phenylpyruvic acid:[1]
This enzyme is a transferase, specifically a transaminase, which transfer nitrogenous groups. The systematic name of this enzyme class is aromatic-amino-acid:2-oxoglutarate aminotransferase. Other names in common use include aromatic amino acid aminotransferase, aromatic aminotransferase, and ArAT. It participates in many metabolic pathways including methionine metabolism, tyrosine metabolism, phenylalanine metabolism, phenylalanine, tyrosine and tryptophan biosynthesis, novobiocin biosynthesis, and alkaloid biosynthesis.[2]
Structural studies
As of late 2007, 13 structures have been solved for this class of enzymes, with PDB accession codes Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, and Template:PDB link.
References
Template:Nitrogenous transferases Template:Enzymes Template:Portal bar