Aralkylamine dehydrogenase (azurin)
Template:Infobox enzyme Aralkylamine dehydrogenase (azurin) (Template:EC number, aromatic amine dehydrogenase, arylamine dehydrogenase, tyramine dehydrogenase) is an enzyme with the systematic name aralkylamine:azurin oxidoreductase (deaminating).[1][2][3][4][5] This enzyme catalyses the following chemical reaction:
- ArCH2NH2 + H2O + 2 azurin ArCHO + NH3 + 2 reduced azurin
The three substrates of this enzyme are RCH2NH2 (i.e., an aromatic amine), water, and the acceptor azurin, and its three products are RCHO, ammonia, and a reduced acceptor. Azurin can be replaced with the artificial acceptor phenazine methosulfate in in vitro studies.[1]
This quinoprotein enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH2 group of donors with other acceptors. This enzyme participates in tyrosine metabolism and phenylalanine metabolism. It is notable for its chemical mechanism, which is dominated by proton tunneling.[6]
References
Template:CH-NH2 oxidoreductases Template:Enzymes Template:Portal bar