Adenosylhomocysteine nucleosidase

Template:Infobox enzyme In enzymology, an adenosylhomocysteine nucleosidase (Template:EC number) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-homocysteine + H₂O $\rightleftharpoons$ S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine

Thus, the two substrates of this enzyme are S-adenosyl-L-homocysteine and H₂O, whereas its two products are S-(5-deoxy-D-ribos-5-yl)-L-homocysteine and adenine.

This enzyme belongs to the family of hydrolases, specifically those glycosylases that hydrolyse N-glycosyl compounds. The systematic name of this enzyme class is S-adenosyl-L-homocysteine homocysteinylribohydrolase. Other names in common use include S-adenosylhomocysteine hydrolase (ambiguous), S-adenosylhomocysteine nucleosidase, 5'-methyladenosine nucleosidase, S-adenosylhomocysteine/5'-methylthioadenosine nucleosidase, and AdoHcy/MTA nucleosidase. This enzyme participates in methionine metabolism.

Structural studies

As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, and Template:PDB link.

References

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