6-methylsalicylic-acid synthase

Template:Short description Template:Infobox enzyme In enzymology, a 6-methylsalicylic-acid synthase (Template:EC number) is a polyketide synthase that catalyzes the chemical reaction

acetyl-CoA + 3 malonyl-CoA + NADPH + H⁺ $\rightleftharpoons$ 6-methylsalicylate + 4 CoA + 3 CO₂ + NADP⁺ + H₂O

The 4 substrates of this enzyme are acetyl-CoA, malonyl-CoA, NADPH, and H⁺, whereas its 5 products are 6-methylsalicylate, CoA, CO₂, NADP⁺, and H₂O.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl-reducing, thioester-hydrolysing and cyclizing). Other names in common use include MSAS, and 6-methylsalicylic acid synthase.

References

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