5-amino-6-(5-phosphoribosylamino)uracil reductase

Template:Short description Template:Infobox enzyme In enzymology, a 5-amino-6-(5-phosphoribosylamino)uracil reductase (Template:EC number) is an enzyme that catalyzes the chemical reaction

5-amino-6-(5-phosphoribitylamino)uracil + NADP⁺ $\rightleftharpoons$ 5-amino-6-(5-phosphoribosylamino)uracil + NADPH + H⁺

Thus, the two substrates of this enzyme are 5-amino-6-(5-phosphoribitylamino)uracil and NADP⁺, whereas its 3 products are 5-amino-6-(5-phosphoribosylamino)uracil, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is 5-amino-6-(5-phosphoribitylamino)uracil:NADP⁺ 1'-oxidoreductase. This enzyme is also called aminodioxyphosphoribosylaminopyrimidine reductase. This enzyme participates in riboflavin metabolism.

Structural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, and Template:PDB link.

References

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