5-Methyltetrahydrofolate:corrinoid/iron-sulfur protein Co-methyltransferase
Template:Short description Template:Infobox enzyme 5-methyltetrahydrofolate:corrinoid/iron-sulfur protein Co-methyltransferase (Template:EC number, acsE (gene)) is an enzyme with systematic name 5-methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase.[1][2][3] This enzyme catalyses the following chemical reaction
- [Methyl-Co(III) corrinoid Fe-S protein] + tetrahydrofolate a [Co(I) corrinoid Fe-S protein] + 5-methyltetrahydrofolate
This enzyme catalyses the transfer of a carbon atom and associated hydrogen atoms from the N5 position of methyltetrahydrofolate to the 5-methoxybenzimidazolylcobamide cofactor of a corrinoid/Fe-S protein, containing a corrin ring similar to that in cobalamin. Although called a methyl transferase, the net transfer is of one carbon atom and two hydrogen atomsTemplate:Dashthe methyltetrahydrofolate contains only two hydrogen atoms more than the tetrahydrofolate. The cobalt atom is able to change oxidation state by obtaining electrons from the 4Fe-4S complex in the protein.[4]
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Template:One carbon transferases Template:Enzymes Template:Portal bar