4-hydroxymuconic-semialdehyde dehydrogenase

Template:Short description Template:Infobox enzyme In enzymology, a 4-hydroxymuconic-semialdehyde dehydrogenase (Template:EC number) is an enzyme that catalyzes the chemical reaction

4-hydroxymuconic semialdehyde + NAD⁺ + H₂O $\rightleftharpoons$ maleylacetate + NADH + 2 H⁺

The 3 substrates of this enzyme are 4-hydroxymuconic semialdehyde, NAD⁺, and H₂O, whereas its 3 products are maleylacetate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 4-hydroxymuconic-semialdehyde:NAD+ oxidoreductase. This enzyme participates in gamma-hexachlorocyclohexane degradation.

References

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