4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase
Template:Short description Template:Infobox enzyme In enzymology, a 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase (Template:EC number) is an enzyme that catalyzes the chemical reaction
- ATP + 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate ADP + 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate
Thus, the two substrates of this enzyme are ATP and 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME), whereas its two products are ADP and 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-MEP).
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol 2-phosphotransferase. This enzyme is also called CDP-ME kinase, and IspE. This enzyme participates in the MEP pathway (non-mevalonate pathway) of isoprenoid precursor biosynthesis.
Structural studies
As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, and Template:PDB link.
References
Template:Non-mevalonate pathway enzymes Template:Kinases Template:Enzymes Template:Portal bar