4,4'-Diapophytoene synthase

Template:Short description Template:Infobox enzyme 4,4'-diapophytoene synthase (Template:EC number, dehydrosqualene synthase, DAP synthase, C30 carotene synthase, CrtM) is an enzyme with systematic name farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase (4,4'-diapophytoene forming). This enzyme catalyses the following chemical reaction

2 (2E,6E)-farnesyl diphosphate $\rightleftharpoons$ 4,4'-diapophytoene + 2 diphosphate (overall reaction)

(1a) 2 (2E,6E)-farnesyl diphosphate $\rightleftharpoons$ diphosphate + presqualene diphosphate

(1b) presqualene diphosphate $\rightleftharpoons$ 4,4'-diapophytoene + diphosphate

This enzyme requires Mn²⁺. It is present in Staphylococcus aureus and some other bacteria such as Heliobacillus sp.

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