3alpha-hydroxysteroid dehydrogenase (A-specific)

Template:Short description Template:Infobox enzyme In enzymology, a 3alpha-hydroxysteroid dehydrogenase (A-specific) (Template:EC number) is an enzyme that catalyzes the chemical reaction

androsterone + NAD(P)⁺ $\rightleftharpoons$ 5alpha-androstane-3,17-dione + NAD(P)H + H⁺

The 3 substrates of this enzyme are androsterone, NAD⁺, and NADP⁺, whereas its 4 products are 5alpha-androstane-3,17-dione, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor, more specifically it is part of the group of hydroxysteroid dehydrogenases. The systematic name of this enzyme class is 3alpha-hydroxysteroid:NAD(P)⁺ oxidoreductase (A-specific).

Structural studies

As of late 2007, 11 structures have been solved for this class of enzymes, with PDB accession codes Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, and Template:PDB link.

References

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