3alpha-hydroxycholanate dehydrogenase

Template:Short description Template:Infobox enzyme In enzymology, a 3alpha-hydroxycholanate dehydrogenase (Template:EC number) is an enzyme that catalyzes the chemical reaction

3alpha-hydroxy-5beta-cholanate + NAD⁺ $\rightleftharpoons$ 3-oxo-5beta-cholanate + NADH + H⁺

Thus, the two substrates of this enzyme are 3alpha-hydroxy-5beta-cholanate and NAD⁺, whereas its 3 products are 3-oxo-5beta-cholanate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is 3alpha-hydroxy-5beta-cholanate:NAD⁺ oxidoreductase. This enzyme is also called alpha-hydroxy-cholanate dehydrogenase.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code Template:PDB link.

References

• Template:Cite journal

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